American College of Obstetrics and Gynecology
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ACOG Committee Opinion
Recently, the American College of Obstetrics and Gynecology released its Committee Opinion regarding prenatal microarray testing, endorsing this cytogenetic technology as an appropriate adjunct to routine karyotyping in pregnancy.
For a reprint of the Committee Opinion,
compliments of Signature Genomics,
please click here.
ACOG Committee Opinion, November 2009
- Conventional karyotyping remains the principal cytogenetic tool in prenatal diagnosis.
- Targeted array CGH, in concert with genetic counseling, can be offered as an adjunct tool in prenatal cases with abnormal anatomic findings and a normal conventional karyotype, as well as in cases of fetal demise with congenital anomalies and the inability to obtain a conventional karyotype.
- Couples choosing targeted array CGH should receive both pretest and posttest genetic counseling. Followup genetic counseling is required for interpretation of array CGH results. Couples should understand that array CGH will not detect all genetic pathologies and that array CGH results may be difficult to interpret.
- Targeted array CGH may be useful as a screening tool.