SignatureChipWG™ and SignatureChipOS™ Comparison
| SignatureChipWG™ | SignatureChipOS™ |
|---|---|
| Advantages | Advantages |
| Whole-genome BAC-array design | Whole-genome oligo-array design |
| Over 4,600 BAC clones | 105K features per array |
| Coverage of more than 150 chromosomal syndrome loci | Coverage of more than 150 chromosomal syndrome loci |
| ~300-fold greater representation of the genome than 44K oligo arrays | An average of 50 oligos per clinical target—five-fold greater coverage than any other clinical oligo arrays |
| >850-band resolution with an average gap size of only 1.6 Mb | Highest-resolution diagnostic chip with Maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions for an unprecedented backbone |
| Genomic backbone targets > 500 genes in critical developmental pathways | > 21% of the genome represented with one probe every 10 kb |
| Less likely to detect copy-number alterations of unclear clinical significance than an oligo array | Detection of small gene alterations which may not be detected by a BAC array |
| BAC-ed by FISH for visualization of chromosome abnormalities | BAC-ed by FISH for visualization of chromosome abnormalities |
| Potential Disadvantages | Potential Disadvantages |
| May miss deletions of genes smaller than the size of the BAC resolution (~80 kb) | More likely to detect copy number alterations of unclear clinical significance |
| May miss small alterations that fall completely within the 1.6 Mb gaps | Alterations that are smaller than the size of a BAC cannot be FISH confirmed |