Current studies indicate that array Comparative Genomic Hybridization, such as SignatureChip® microarray testing, yields 2–5 times more diagnostic information than traditional cytogenetics (chromosome analysis and FISH) in the evaluation of individuals with unexplained intellectual disability, autism, failure to thrive, or multiple congenital anomalies.
To learn more, please call 1.877.SigChip to speak with one of our Genetic Couneslors, or email us with any questions.
Selected References:
- Bejjani BA, Shaffer LG. (2008). Clinical utility of contemporary molecular cytogenetics. Annu Rev Genomics Hum Genet. 2008; 9:71-86.
- Vissers, L.E., de Vries, B.B., Osoegawa, K., Janssen, I.M., Feuth, T., Choy, C.O., Straatman, H., van der Vliet, W., Huys, E.H., van Rijk, A., et al. (2003). Array-based comparative genomic hybridization for the genomewide detection of submicroscopic chromosomal abnormalities. Am. J. Hum. Genet. 73, 1261–1270.
- Shaw-Smith, C., Redon, R., Rickman, L., Rio, M., Willatt, L., Fiegler, H., Firth, H., Sanlaville, D., Winter, R., Colleaux, L., et al. (2004). Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. J. Med. Genet. 41, 241–248.