SignatureChipWG™
This microarray includes over 5,600 BAC clones and interrogates substantially more genomic regions not included in the Signature PrenatalChip®. In prenatal cases that present with suspicion for an underlying structural chromosome abnormality diagnosable by microarray technology, a prenatal sample can be evaluated by the SignatureChipWG™.
Indications for Use
Signature Genomics suggests the SignatureChipWG™ in pregnancies with:
- Abnormal ultrasound findings with normal karyotype
- Abnormal fetal karyotype with a mosaic chromosome imbalance
- Family history of known or suspected chromosome abnormality
The decision to evaluate at this level must be balanced against the possibility of finding results of unclear clinical significance. This approach can provide a higher-resolution analysis of chromosome structure in certain cases, and Signature Genomics encourages the health care provider to contact one of our board-certified genetic counselors to discuss the case prior to submitting a sample.
Technical Specifications
- BAC-based microarray
- >5600 BAC clones
- >200 Clinically recognized syndromes
- BAC clones in every band at the 850 band level
- 5 Mb dense coverage in subtelomeric regions
- 5 Mb dense coverage in pericentromeric regions
- Average gap size is 600 kb