Signature PrenatalChip®
This BAC-based array with over 2,100 validated probes evaluates over 100 clinically recognized genetic syndromes plus the subtelomeric and pericentromeric regions. The Signature PrenatalChip® was developed to provide microarray testing in prenatal cases in which the suspicion for a chromosome imbalance in the pregnancy exists, but is relatively low.
The Signature PrenatalChip® is specifically designed to take advantage of the ability of microarray technology to find smaller alterations than can be detected by routine karyotyping while minimizing the potential to detect chromosome structural alterations with unknown clinical relevance.
Indications for Use
Signature Genomics suggests the Signature PrenatalChip® in pregnancies in which the suspicion for a chromosome imbalance exists but is relatively low. Such indications include:
- Advanced maternal age
- Parental concern/anxiety
The Signature PrenatalChip® may be an appropriate choice for prenatal samples in which the pregnancy history and prenatal screening tests including ultra-sounds and maternal blood studies have been normal and the patient requests additional genetic testing.
Technical Specifications
- BAC-based microarray
- Over 2,100 BAC clones
- 100 Clinically recognized syndromes
- 10 Mb coverage in subtelomeric regions
- 5 Mb coverage in pericentromeric regions