Signature PrenatalChip®
The Signature PrenatalChip® is a specifically designed diagnostic microarray that interrogates only specific regions associated with mental retardation and malformation syndromes. Specific loci have been excluded which are associated with adult-onset conditions. Parental samples are analyzed in conjunction with the prenatal sample to minimize findings of uncertain clinical significance.
Please see our Prenatal Diagnosis Services page for more information about prenatal microarray analysis.
Signature PrenatalChip® Version 1.0 characteristics
- 1083 BAC clones (PrenatalChip® Clone List)
- 367 BAC contigs are evaluated in each experiment, representing over 70 recognized genetic syndromes, plus all 41 unique subtelomeric regions, and all 43 unique pericentromeric regions (view regions assayed by the PrenatalChip®)
- Pseudoautosomal clones detect sex chromosome numerical abnormalities
- Pericentromeric probes detect locus-centric marker chromosomes
- Each clone is validated and mapped with standard FISH techniques at Signature Genomic Laboratories to ensure accurate test results
- High resolution – detects alterations as small as 80-100 Kb
- Minimum of three overlapping BAC clones at each locus for more comprehensive coverage
- Positive controls for each disease locus
- Each test is performed twice using dye-reversal strategy
- Opposite-sex controls are utilized to provide a built-in control with each analysis