Signature PrenatalChip®OS
The Signature PrenatalChip®OS features high-density coverage of the genome and is the most comprehensive clinically-relevant oligonucleotide-based microarray for diagnostic use.
This array:
- Evaluates over 200 known genetic syndromes and over 500 gene regions of functional significance in human development.
- Also known as the SignatureChipOS™, this is the microarray of choice for Pediatric/ Adult cases.
- Has an increased diagnostic yield for clinically significant chromosome imbalances when compared to the NEW Signature PrenatalChip®TE.
This microarray is presently used by many clinicians for their prenatal cases with:
- Abnormal fetal karyotypes requiring molecular clarification
- Stillbirth/fetal loss or therapeutic termination
- Ultrasound abnormalities or multiple congenital anomalies, in which parents or physicians desire comprehensive evaluation of the genome to maximize diagnostic yield, but also understand that there is an increased potential to find results of unclear significance.
Signature PrenatalChip®OS characteristics
- 135,000 oligonucleotides evaluated in each experiment, representing over 200 recognized genetic syndromes, plus all 41 unique subtelomeric regions, and all 43 unique pericentromeric regions. (View regions tested by the Signature PrenatalChip®OS)
- Maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions.
- Pseudoautosomal probes detect sex chromosome numerical abnormalities
- Pericentromeric probes detect locus-centric marker chromosomes