Sample Requirements and Turn-Around Times

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Signature Precision Panel™ | Prenatal
Sample Type Quantity Required Turn-around Times*
 

Precision PanelAlone

Precision Panel+Karyotype

Precision Panel Karyotyping
Percutaneous Umbilical Blood Sampling (PUBS) 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 1-3cc 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 1-3cc 24-48 hours ≤10 days
DNA

7-10µg
Please read DNA Acceptance Policy

N/A 24-48 hours N/A
Cultured CVS or Amniocytes 1 x T-75 flask or 3 x T-25 flasks
(70% confluent)
1 x T-75 flask or 3 x T-25 flasks (70% confluent) 24-48 hours ≤10 days
Amniotic Fluid 5–10cc** 15-25cc 24-48 hours ≤10 days
Chorionic Villus Sampling (CVS) 3–5mg tissue in sterile media
or saline
15-30mg tissue in sterile media or saline 24-48 hours ≤10 days
Placental Tissue/Products of Conception (POC) Lab will attempt to work with
the specimen received
Lab will attempt to work with the specimen received Please contact Signature Genomics

Please contact Signature Genomics

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Signature Microarrays
Sample Type Quantity Required Turn-around Times*
  Microarray Alone Microarray + Abridged Karyotype Microarray Alone
Peripheral Blood 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3–5cc whole blood 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc whole blood 7 days
Neonatal Peripheral Blood 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 1cc whole blood, or 1 tube (1 x NaHep) containing 2cc whole blood 1 NaHep vacutainer containing 1.5-2cc whole blood and 1 EDTA vacutainer containing 1cc whole blood 7 days
Skin Biopsy 1 x T-75 flask or 3 x T-25 flasks (70% confluent) or 3mm x 3mm biopsy in sterile media or saline 1 x T-75 flask or 3 x T-25 flasks (70% confluent) or 3mm x 3mm biopsy in sterile media or saline CULTURED CELLS: 7 days
TISSUE: Please contact Signature Genomics
DNA 10µg
Please read DNA Acceptance Policy
N/A 7 days
Cultured CVS or Amniocytes 1 x T-75 flask or 3 x T-25 flasks (70% confluent) 1 x T-75 flask or 3 x T-25 flasks (70% confluent), plus 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc maternal whole blood 7 days
Amniotic Fluid 15–20cc** 15-25cc**, plus 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc maternal whole blood 7 days
Chorionic Villus Sampling (CVS) 5–10mg tissue in sterile media or saline 15-30mg tissue in sterile media or saline, plus 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc maternal whole blood 7 days
Placental Tissue/Products of Conception (POC) 1 x T-75 flask or 3 x T-25 flasks (70% confluent) or 15–20mg tissue in sterile media or saline 1 x T-75 flask or 3 x T-25 flasks (70% confluent) or 15-20mg tissue in sterile media or saline, plus 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc maternal whole blood CULTURED CELLS: 7 days
TISSUE: Please contact Signature Genomics

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Signature FISH
Sample Type Quantity Required Turn-around Times*
Peripheral Blood 1 NaHep vacutainer containing 3–5cc whole blood 7–10 days
Neonatal Peripheral Blood 1 NaHep vacutainer containing 1.5-2cc whole blood 7-10 days
Skin Biopsy 1 x T-75 flask or 3 x T-25 flasks (70% confluent)
or 3mm x 3mm biopsy in sterile media or saline
CULTURED CELLS: 7–10 days
TISSUE: Please contact Signature Genomics
Cultured CVS or Amniocytes 1 x T-75 flask or 3 x T-25 flasks (70% confluent) 7–10 days
Amniotic Fluid 15–20cc** 7–10 days
Chorionic Villus Sampling (CVS) 5–10mg tissue in sterile media or saline 7–10 days
Placental Tissue/Products of Conception (POC) 1 x T-75 flask or 3 x T-25 flasks (70% confluent)
or 15–20mg tissue in sterile media or saline
CULTURED CELLS: 7–10 days
TISSUE: Please contact Signature Genomics

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Signature Karyotype
Sample Type Quantity Required Turn-around Times*
Peripheral Blood 1 NaHep vacutainer containing 3–5cc whole blood ≤10 days
Neonatal Peripheral Blood 1 NaHep vacutainer containing 1.5-2cc whole blood ≤10 days
Skin Biopsy 1 x T-75 flask or 3 x T-25 flasks (70% confluent)
or 3mm x 3mm biopsy in sterile media or saline
CULTURED CELLS:
10–14 days
TISSUE: Please contact Signature Genomics
Cultured CVS or Amniocytes 1 x T-75 flask or 3 x T-25 flasks (70% confluent) ≤10 days
Amniotic Fluid 15–20cc** ≤10 days
Chorionic Villus Sampling (CVS) 15–30mg tissue in sterile media or saline ≤10 days
Placental Tissue/Products of Conception (POC) 1 x T-75 flask or 3 x T-25 flasks (70% confluent) or 15–20mg tissue in sterile media or saline CULTURED CELLS:
10–14 days
TISSUE: Please contact Signature Genomics

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Other
Test Type Quantity Required Turn-around Times*
MCC 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc whole blood Please contact Signature Genomics
Fragile X 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3-5cc whole blood Please contact Signature Genomics
Fragile X - Neonatal Blood 1 EDTA vacutainer containing 1 cc whole blood Please contact Signature Genomics
AFP with reflex to AChE 3cc of direct amniotic fluid Please contact Signature Genomics
AChE 1cc of direct amniotic fluid Please contact Signature Genomics

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General Specimen Handling Instructions

  • Label all tubes/flasks with patient name and date of birth. Enclose completed Requisition Form. Include previous cytogenetic reports.
  • Samples should be shipped at room temperature in a rigid, leak-proof container by overnight delivery. Signature Genomics provides specimen collection kits free of charge.
  • For paraffin-or formalin-embedded tissue, please contact Signature Genomics.

*Turn-around times are approximate and based on receipt of adequate sample. Other services at Signature Genomics, such as cell culturing, culture expansion, karyotyping, or FISH confirmation, may increase turn-around times.

**Additional specimen is desired if add-on or reflex tests are being considered.

Additional CPT codes may be billed if the sample received does not meet Signature Genomics specimen requirements.


1.877.Sig.Chip (744.2447) or 509.474.6840  •  info@signaturegenomics.com

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