Sample Requirements and Turn-Around Times
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- Signature Precision Panel™ | Prenatal + Karyotype
- Signature Precision Panel™ | Prenatal Alone
- Signature Microarrays
- Signature FISH
- Signature Karyotype
- Other
| Signature Precision Panel™ | Prenatal Alone | ||
|---|---|---|
| Sample Type | Quantity Required | Turn-around Times* |
| Peripheral Blood | 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3–5 cc whole blood | 24–48 hours |
| DNA | 7–10 µg Please read DNA Acceptance Policy |
24–48 hours |
| Cultured CVS or Amniocytes | 1 x T-75 flask or 3 x T-25 flasks (70% confluent†) |
24–48 hours |
| Amniotic Fluid | 5–10cc | 24–48 hours |
| Chorionic Villus Sampling (CVS) | 3–5 mg tissue in sterile media or saline | 24–48 hours |
| Placental Tissue/Products of Conception (POC) | Lab will attempt to work with whatever is received |
Please contact Signature Genomics |
| Signature Microarrays | ||
|---|---|---|
| Sample Type | Quantity Required | Turn-around Times* |
| Peripheral Blood | 2 tubes (1 x NaHep and 1 x EDTA vacutainer) each containing 3–5cc whole blood | 7 days |
| Skin Biopsy | 1 x T-75 flask or 3 x T-25 flasks (70% confluent†) or 3mm x 3mm biopsy in sterile media or saline | CULTURED CELLS: 7 days TISSUE: Please contact Signature Genomics |
| DNA | 10µg Please read DNA Acceptance Policy |
7 days |
| Cultured CVS or Aminocytes | 1 x T-75 flask or 3 x T-25 flasks (70% confluent†) | 7 days |
| Amniotic Fluid | 15–20cc | Please contact Signature Genomics |
| Chorionic Villus Sampling (CVS) | 5–10mg tissue in sterile media or saline | Please contact Signature Genomics |
| Placental Tissue/Products of Conception (POC) | 1 x T-75 flask or 3 x T-25 flasks (70% confluent†) or 15–20mg tissue in sterile media or saline | CULTURED CELLS: 7 days TISSUE: Please contact Signature Genomics |
General Specimen Handling Instructions
- Label all tubes/flasks with patient name and date of birth, and enclose completed paperwork. Include previous cytogenetic reports.
- Samples should be shipped at room temperature in a rigid, leak-proof container by overnight delivery. Delayed shipment of sample or inappropriate temperatures may result in longer processing time or sample failure. Please notify Laboratory of courier tracking number.
- Microarray turn-around times are usually 5–7 days for sufficient samples. If culturing is needed, or other services are requested, turn-around times may be longer. Samples received prior to 12:00pm (PT) are processed the same day, whereas samples received in the afternoon are processed the next working day.
- For paraffin- or formalin-embedded tissue, please contact Signature Genomics.
- Please contact laboratory at 509-474-6840 for further clarification or other questions.
* Turn-around times are based upon receipt of adequate sample for microarray analysis. Other Signature services, such as cell culturing, culture expansion, karyotyping, or FISH confirmation, may increase turn-around times.
† Additional CPT codes may be billed if the sample received does not meet Signature Genomics specimen requirements.