SignatureChipOS®
The SignatureChip® Oligo Solution™ (SignatureChipOS®) oligonucleotide-based microarray was specifically designed, developed and validated by cytogeneticists exclusively for clinical applications.
The 135,000 oligonucleotides on the SignatureChipOS cover every region known to be involved in cytogenetic abnormalities, including over 245 recognized genetic syndromes, over 980 gene regions of functional significance in human development, the pericentromeric regions, and the subtelomeres. The SignatureChipOS has average probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in regions of clinical relevance.
Many abnormalities detected by the SignatureChipOS can be visualized by FISH. FISH visualization is essential for accurate diagnosis and determination of recurrence risks; it provides information about the nature and causative mechanism of the chromosome alteration. This offers you and your patients unparalleled information that you can use for diagnosis and accurate genetic counseling.
SignatureChipOS features
- 135,000 oligonucleotides evaluated, representing over 245 recognized genetic syndromes, over 980 gene regions of functional significance in human development, and subtelomeric and pericentromeric regions. (View syndromes tested by the SignatureChipOS)
- Average probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in regions of clinical relevance
- Probes along the X and Y chromosomes detect sex chromosome numerical abnormalities