Clinicians have a choice when ordering tests from Signature Genomic Laboratories: BAC or oligo. The SignatureChip Oligo Solution™ (SignatureChipOS™) oligonucleotide-based microarray was specifically designed, developed and validated by cytogeneticists exclusively for clinical applications.

The 105,000 oligonucleotides on the SignatureChipOS cover every region known to be involved in cytogenetic abnormalities, including over 150 syndromes, the pericentromeric regions, and subtelomeres. With a maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions, for an average of 50 oligos per clinical locus—a five-fold increase over any other clinical oligo microarray—the SignatureChipOS covers more conditions at higher density than any other microarray available.

Because the SignatureChipOS covers the same regions as the SignatureChipWG™ BAC array, almost every abnormality detected by the SignatureChipOS can be visualized by FISH. FISH visualization is essential for accurate diagnosis and determination of recurrence risks; it provides information about the nature and causative mechanism of the chromosome alteration. The SignatureChipOS is the only oligo array available that is backed by FISH, offering you and your patients unparalleled information that you can use for diagnosis and accurate genetic counseling.

The SignatureChipOS offers the best of the oligo and BAC worlds: the high resolution of oligos with the clinical confidence provided by BAC confirmation of abnormalities. And with our proprietary Oligoglyphix analysis software, the SignatureChipOS provides rapid and accurate results. You know you’ve made the correct choice for array-based chromosome analysis.

Click here to compare the SignatureChipOS and SignatureChipWG.

SignatureChipOS characteristics

• 105,000 oligonucleotides evaluated in each experiment, representing over 150 recognized genetic syndromes, plus all 41 unique subtelomeric regions, and all 43 unique pericentromeric regions (click here to view regions tested by the SignatureChipOS)
• Maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions, for an average of 50 oligos per clinical locus
• Contigs of probes in every band at 850-band resolution
• Pseudoautosomal probes detect sex chromosome numerical abnormalities
• Pericentromeric probes detect locus-centric marker chromosomes

Construction

• Based upon the latest genomic microarray technology
• Designed and validated in-house at Signature Genomic Laboratories (click here to learn more about Signature Genomic Laboratories)
• Each locus is validated and mapped with standard FISH techniques at Signature Genomic Laboratories to ensure accurate test results

Design

• Proprietary design provides absolute confidence in results
• High resolution
• The only oligo-based array BAC-ed by FISH for visualization of abnormal results.
• Positive controls for each disease locus

Unmatched Experience and Service

• Over 20,000 clinical samples processed – more than double the volume of other diagnostic laboratories combined
• Founders Lisa G Shaffer, Ph.D., FACMG and Bassem A. Bejjani, M.D., FACMG have over 25 years of combined experience in clinical and diagnostic genetics
• FISH confirmation of abnormal results at no charge
• Comprehensive report and interpretation provided by a board-certified cytogeneticist (click here to learn more about Signature Services)
• Consultations available with a board-certified genetic counselor on abnormal results
• Consistent 5-7 day turnaround time
• Saturday delivery

More Signature Advantages

• Analysis does not require living cells (click here to view Sample Requirements)
• Less subject to interpretation errors compared to routine cytogenetics
• Less labor resulting in faster results and competitive pricing
• Comprehensive information for better patient diagnosis and management

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