SignatureChipOS™
The SignatureChip Oligo Solution™ (SignatureChipOS™) oligonucleotide-based microarray was specifically designed, developed and validated by cytogeneticists exclusively for clinical applications.
The 135,000 oligonucleotides on the SignatureChipOS cover every region known to be involved in cytogenetic abnormalities, including over 200 syndromes, the pericentromeric regions, and subtelomeres. With a maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions.
Almost every abnormality detected by the SignatureChipOS can be visualized by FISH. FISH visualization is essential for accurate diagnosis and determination of recurrence risks; it provides information about the nature and causative mechanism of the chromosome alteration. The SignatureChipOS is the only oligo array available that is backed by FISH, offering you and your patients unparalleled information that you can use for diagnosis and accurate genetic counseling.
SignatureChipOS characteristics
- 135,000 oligonucleotides evaluated in each experiment, representing over 200 recognized genetic syndromes, plus all 41 unique subtelomeric regions, and all 43 unique pericentromeric regions. (View regions tested by the SignatureChipOS)
- Maximum probe spacing of one probe every 35 kb throughout the genome and one probe every 10 kb in clinical regions.
- Pseudoautosomal probes detect sex chromosome numerical abnormalities
- Pericentromeric probes detect locus-centric marker chromosomes