Signature Technology

Signature Genomic Laboratories offers four proprietary microarrays for the detection of chromosome abnormalities in individuals with developmental delay, mental retardation, seizures, and other developmental abnormalities: The SignatureChipWG™, the SignatureChipOS™, and Signature PrenatalChip®. See below for more information about each of our products.

Signature microarrays are designed, manufactured and validated in-house at Signature Genomic Laboratories. Signature microarrays are used exclusively by Signature Genomic Laboratories and are not for sale to other laboratories.

Signature Genomic Laboratories Technology Summary

	SignatureChipWG™	SignatureChipOS™	Signature PrenatalChip®
Indications for appropriate ordering:	Pediatric and adult patients with mental retardation, developmental delay, dysmorphic features, birth defects, behavior problems, and other medical issues suggestive of a chromosome abnormality syndrome	Pediatric and adult patients with mental retardation, developmental delay, dysmorphic features, birth defects, behavior problems, and other medical issues suggestive of a chromosome abnormality syndrome	Pregnancies for which cytogenetic testing would normally be offered
Type of probe	BAC	oligonucleotide	BAC
# of probes	4670	105,000	1083
# of loci	1543	1543*	367
Coverage of microdeletion/ microduplication regions	Yes	Yes	Yes
Coverage of subtelomeric regions	Yes	Yes	Yes
Coverage of pericentromeric regions	Yes	Yes	Yes
	Learn more about the SignatureChipWG™	Learn more about the SignatureChipOS™	Learn more about the PrenatalChip®
*Between targeted loci there is one clone every 35kb.

Construction

• Based upon the latest genomic microarray technology
• Designed, manufactured and validated in-house at Signature Genomic Laboratories (click here to learn more about Signature Genomic Laboratories)
• Each clone is validated and mapped with standard FISH techniques at Signature Genomic Laboratories to ensure accurate test results

Design

• Proprietary design provides absolute confidence in results
• High resolution – detects alterations as small as 50-100 kb, depending on platform
• Overlapping clones at each locus for more comprehensive coverage
• Positive controls for each disease locus
• Each test is performed twice using dye-reversal strategy
• Opposite-sex controls are utilized to provide a built-in control with each analysis

Unmatched Experience and Service

• Over 20,000 clinical samples processed – more than double the volume of other diagnostic laboratories combined
• Founders Lisa G Shaffer, Ph.D., FACMG and Bassem A. Bejjani, M.D., FACMG have over 25 years of combined experience in clinical and diagnostic genetics
• FISH confirmation of abnormal results at no charge
• Comprehensive report and interpretation provided by a board-certified cytogeneticist (click here to learn more about Signature Services)
• Consultations available with a board-certified genetic counselor on abnormal results
• Parental testing offered at no charge for abnormal test results found by Signature Genomics (click here to view Parental Testing Policy)
• Consistent 3-7 day turnaround time
• Saturday delivery

More Signature Advantages

• Analysis does not require living cells (click here to view Sample Requirements)
• Less subject to interpretation errors as compared to routine cytogenetics
• Less labor resulting in faster results and competitive pricing
• Comprehensive information for better patient diagnosis and management

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